mangosteenA tropical fruit native to Southeast Asia has been shown in a new study to protect against breast cancer. Researchers from the University of Chinese Academy of Sciences’ (UCAS) College of Life Sciences found that the pericarp of the mangosteen fruit, which is commonly grown in Thailand and Malaysia, contains a unique compound that triggers apoptosis, or cell death, in breast cancer cells.

A followup to a previous study on mangosteen’s effects in vitro, this latest research looked at the effects of a unique mangosteen xanthone on actual human breast cancer cells. The team from UCAS studied how alpha-mangostin affects fatty acid synthase, or FAS, a multi-enzyme protein that catalyzes the formation of long-chain fatty acids from various compounds. Over-expression of FAS is also commonly observed in conjunction with breast cancer occurrence.

Using a battery of tests, the researchers found that alpha-mangostin exhibits an inhibitory effect on the expression of FAS, in turn resulting in a decrease of intracellular fatty acid accumulation. Additionally, alpha-mangostin noticeably triggers apoptosis in human breast cancer cells, regulating the expression of other key proteins involved in apoptosis.

“Alpha-mangostin could effectively suppress FAS expression and inhibit intracellular pro-apoptotic proteins of the Bcl-2 family.”

Be careful to choose mangosteen products that are free of toxic heavy metals

Based on these successful findings, UCAS scientists say mangosteen xanthones could eventually become a viable treatment agent in breast cancer therapy. And since it is relatively easy to source, mangosteen extract could also be used as a preventive food for avoiding breast cancer development.

Our readers need to be aware, however, that not all mangosteen products are equal. As we reported back in April, at least one major supplier of dried mangosteen powder to the U.S. is delivering a product that is exceptionally high in the brain-damaging metal lead. This same powder, which is commonly repackaged for various retail supply chains, was also found to contain aluminum, arsenic, cadmium and some mercury.

Fresh mangosteen or verified powders are an excellent ‘superfood’

However, awareness about the presence of heavy metals in food is growing, which means the availability of safer alternatives will only increase. All in all, sourcing fresh mangosteen or verified mangosteen powder is still a great way to take advantage of this powerful anticancer superfood.

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How It Works

Various studies have shown that phytoceuticals in Mangosteen (in some cases known to be its xanthones) have properties such as: anti-tumor (shrinks tumors), anti-leukemia, antifungal (critical for all cancer patients), antibacterial (to protect DNA), antioxidants (at least two dozen different kinds of xanthones are in the mangosteen fruit), antiproliferation, kills cancer cells and causes apoptosis (programmed cell death) for some types of cancer. This is a pretty impressive list of cancer credentials!

Mangosteen Treatment

In keeping with the superb anti-cancer properties of many kinds of fruits, especially grapes and berries, mangosteen can be added to this exclusive list.

The mangosteen fruit (Garcinia mangostana L.) is grown in Thailand, Cambodia, Vietnam, India and several other countries. Most of the scientific research on this fruit involves about a half dozen of the two dozen known xanthones in this fruit. Most of the xanthones in Mangosteen have yet to be researched. Mangosteen has a wide range of benefits, perhaps most result from its xanthone phytoceuticals/antioxidants. However, mangosteen also contains: catechins, polyphenols, minerals and vitamins.

As an antioxidant, mangosteen is very high among plants:

A new laboratory test known as ORAC (Oxygen Radical Absorbance Capacity) has also shown that an ounce of mangosteen juice has 20 to 30 times the ability to absorb free radicals than one ounce of most fruits and vegetables. The ORAC test is one of the most accurate ways to measure the ability of antioxidants in a certain substance to absorb free radicals. The higher the ORAC score, the better the food is for the body.
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Here are some of the xanthones in mangosteen:

  • alpha-Mangostin
  • beta-Mangostin
  • 3-Isomangostin
  • Mangostanol
  • Gertanin
  • Garcinone A
  • Garcinone B
  • Garcinone C
  • Garcinone D
  • Garcinone E
  • Maclurin

In terms of direct studies on cancer, the following quote is related to cancer:

We found that antiproliferative effect of CME [crude methanolic extract] was associated with apoptosis on breast cancer cell line by determinations of morphological changes and oligonucleosomal DNA fragments. In addition, CME at various concentrations and incubation times were also found to inhibit ROS production. These investigations suggested that the methanolic extract from the pericarp [skin] of Garcinia mangostana had strong antiproliferation, potent antioxidation and induction of apoptosis. Thus, it indicates that this substance can show different activities and has potential for cancer chemoprevention which were dose dependent as well as exposure time dependent.

Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line,” by Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N.

Heres is another study:

Our results have shown that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect on all HCC cell lines as well as on other gastric and lung cancer cell lines included in the screen. We suggest that garcinone E may be potentially useful for the treatment of certain types of cancer.

Garcinone E, a Xanthone Derivative, has Potent Cytotoxic Effect Against Hepatocellular Carcinome Cell Lines” by Chi-Kuan Ho, Yu-Ling Huang and Chieh-Chih Chen

Some of the more impressive research on mangosteen involve leukemia:

We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.

Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines,” by Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.

More mangosteen scientific studies can be found at:
http://www.raysahelian.com/mangosteen.html

One of the nice things about mangosteen is not only that it tastes good, but is also anti-diarrheal, meaning you are not likely to get diarrhea from drinking too much Mangosteen.

Here is how to get toally unbiased information about Mangosteen (from Dr. Duke):

This is the world famous Dr. Duke’s Agricultural Research Service:

  1. Click on this website: http://www.ars-grin.gov/duke/
  2. Click on Chemicals and activities,
  3. Select ‘Common Name’ then type in ‘mangosteen’ in the search box,
  4. Select ‘Print chemical activities after chemicals’ then Submit Query. Read all the way down the page.

Important Comments

Important Warning: Due to the fact that many cancer patients have liver damage, frequently due to chemotherapy, and due to the fact that high doses of this product may, in rare cases, contribute to liver damage; doses of this product should not exceed 3 or 4 ounces a day. Those who already have liver damage should avoid this product.

Sources for this article include:

http://www.ncbi.nlm.nih.gov
http://science.naturalnews.com

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Comments
  1. Nicole says:

    Can you recommend a brand to buy in the UK please?

    Like

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