Iodine and Companion Nutrients

  • 50 mg Iodoral minimum for breast cancer (may start with 12.5 mg).
    Some practitioners may recommend another form of iodine such as
    Lugol’s solution. Iodoral is the Lugol’s formula in tablet form especially designed to avoid gastric irritation.
  • Vitamin C – 3,000 mg per day (more may be necessary to detox bromide).
  • 300-600 mg magnesium oxide (Iodine Investigation Project participants prefer magnesium glycinate or magnesium citrate.)
  • 200 mcg selenium. The selenomethionine version is preferred by many.
  • 500 mg niacin (B3) twice a day (NOT niacinamide). Start lower to avoid flush.
  • 100 mg Vitamin B2 three times a day.
  • A comprehensive vitamin and nutrition program.
  • (Feb 2008) Dr. Guy Abraham cautions that “excess calcium supplementation (2,000-
    3,000 md/day) has been the most common cause of poor response to iodine
    supplementation.” Vitamin Research News Vol. 22. Number 2.

24 Hour Iodine Loading Test Now Essential

The Iodine specialists have recently discovered it is essential to have the 24 Hour Iodine Loading Test before implementing iodine supplementation in order to investigate the presence of a possible iodine absorption defect. If a patient has a normal or high Loading Test score in the presence of known iodine deficiency condition such as breast or thyroid
disease, a defect in the Sodium Iodide Symporter (NIS) mechanism is suspected. The iodine taken during the loading test may pass into the urine unabsorbed giving a false normal reading. Follow your physician’s iodine dosing carefully to see how the iodine test
result changes.

  • The doctors find that the most common side effects are usually resolved with 3 grams of vitamin C and/or the salt loading protocol.
  • Be aware of iodine-related bromide detox symptoms. Symptoms of “bromism” may occur in some people. Patients
    are usually advised to cut back on iodine, *pulse-dose (see below) and saltload more frequently.

  • Important: The following protocol should be implemented only under your doctor’s supervision and monitored with the appropriate laboratory work and thyroid studies.
    Report any side effects to your physician. Do not take iodine if you are allergic to iodized

    Salt Loading Protocol for Possible Bromide Side

    Orthoiodosupplementation induced and increased mobilization of bromine from storage sites, with increased urinary excretion of bromide. –Guy Abraham, MD

    Certain iodine-literate doctors feel the bromide excreted by iodine therapy can be eliminated more efficiently by the chloride present in mineral-rich unprocessed sea salt.
    The salt is added to water in a specific way. Eating salty food is not effective. DO NOT USE TABLE SALT

    Many iodine takers found the Salt Loading Protocol devised by Dr. William Shevin (and
    presented at the February ’07 Iodine Conference) to be effective in eliminating the side
    effects such as bromide sedation, acne, brain fog, brassy taste, mouth sores, frontal
    headache or other symptoms which occur in a small percentage of patients.
  • 1/4 teaspoon salt dissolved in 1/2 cup warm water. Follow immediately with 12-16
    oz pure water.
  • Repeat in 30-45 minutes if needed. May repeat again until copious urination begins.
  • Observe subjective response (usually within several hours).
  • Iodine Investigation Project participants have found 1/2 teaspoon salt dissolved in
    the recommended amount of water works faster than the 1/4 teaspoon dosage.



1. Brownstein, Why You Need It, Why You Can’t Live Without It, (Third Edition) Medical Alternative Press,
West Bloomfield, MI 2006. See

2. Abraham, GE, The Historical Background of the Iodine Project, The Original Internist 2005

3. Abraham, GE, Iodine Supplementation Markedly Increases Urinary Excretion of Fluoride and Bromide,
Townsend Letter 2003

4. Abraham, G.E., Brownstein, D., Evidence that the administration of Vitamin C improves a defective
cellular transport mechanism for iodine: A case report. The Original Internist, 12(3):125-130, 2005

[excerpt] Elevated bromide levels were observed in urine and serum samples, twenty times the levels
reported in the literature in normal subjects(8,9). Mild bromism may have been the cause of the oxidative
damage to the iodine transport system and the side effects to orthoiodosupplementation. Chloride
competes with bromide at the renal level and increases the renal clearance of bromide (10,11). Sodium
chloride at 10 gm/day for one week resulted in marked increase in urine bromide levels, and a sharp
drop in serum bromide. While on the chloride load, urinary frequency improves for the first time in 5
years, but fatigue worsened and she experienced facial and body acne. No significant change in
symptomatology was observed while on Vitamin C. The responses of her symptoms to various
treatments modalities by self-assessment are summarized in Table I. The treatment modalities are
cumulative and added sequentially in the patient’s management. Measurements of serum and urine
bromide and iodide levels reported in this manuscript were performed by ion-selective electrode assay,
following chromatography on strong anion exchanger cartridges, as previously described (3,7).



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